Administration of Buccal Seizure Medication

<< NEUROLOGICAL


Given that when a child is having a seizure, it can be a stressful situation, it is highly recommended that you familiarize yourself with that child’s seizure emergency care plan before hand


Considerations:

  • Given that the medication can be dispensed in different formats and dosages, the school nurse should always review the medication and order upon receiving it at the school
  • Given that when a child is having a seizure, it can be a stressful situation, it is highly recommended that you familiarize yourself with that child’s seizure emergency care plan beforehand
    • NOTE: The student’s Seizure Action Plan should indicate when 911 should be called (i.e. on immediate onset of a seizure, after the student has been having a seizure for 5 minutes, or if the student hasn’t responded to the rescue medication, etc.)
  • Store the Seizure Action Plan in a location that is easily accessible during a seizure
  • Store the Seizure Observation Recording Form with the seizure medication
  • Secured, but accessible storage of the medication should be considered in your medication administration plan
  • The school nurse should develop a plan to systematically check the expiration date on the medication to ensure the medication has not expired
    • Lorazepam expires 90 days after it has been opened and requires refrigeration
    • Midazolam can be stored at room temperature and there is no specific expiration date once the medication has been opened (other than the actual expiration date printed on medication)
  • Be sure to ensure the child’s privacy and confidentiality when calling for assistance. 
  • Do not say the child’s name over the PA system or walkie-talkie
  • If possible, have someone assist with removing onlookers and other students to provide the child with privacy
  • NOTE:  The Food and Drug Administration (FDA) has not approved lorazepam or midazolam for administration via this medication route.  Since healthcare providers are currently prescribing the medications via this route, if you have questions or concerns, discuss this with the prescribing healthcare provider or the pharmacist


Supplies:

  • Seizure Action Plan/Healthcare provider’s order
  • Student’s Individualized Healthcare Plan
  • Seizure Observation Recording Form
  • Medication
  • Syringe or dropper
  • Gloves
  • Gauze or paper towel

First aid for a seizure:

  1. If someone is present, have them call for assistance
  2. East the student onto a flat surface such as the floor being sure not to move the child any more than is necessary
  3. Turn the child onto his/her side to allow vomit/phlegm to be expelled rather than inhaled
  4. Place something soft under the child’s head to protect them from injury
  5. Ensure the child’s airway is not obstructed
  6. Loosen tight clothing around the child’s neck
  7. Do not restrict the child’s arms or legs
  8. Ensure there is no furniture or objects close to the child that could injure him/her
  9. Review the child’s emergency care plan
  10. Gather the emergency medication and needed supplies in case seizure lasts longer than designated time frame

Procedure:                                                  

  1. Identify that symptoms of a prolonged seizure are present and that based on the student’s Seizure Action Plan/healthcare provider’s order, that medication needs to be given
  2. Call for assistance, if you have not already done so
    • As that another school staff person call 911 or emergency medical servics, if indicated on the student’s Seizure Action Plan
    • NOTE: The student’s Seizure Action Plan should indicate when 911 should be called (i.e. on immediate onset of seizure after the student has been having a seizure for 5 minutes, or if the student has not responded to rescue medication
  3. Note time of seizure onset on Seizure Observation Recording Form
  4. If student is not already in a side lying position, move them to a side lying position, if possible
  5. Explain the procedure to the student at their level of understanding
  6. If possible, wash your hands
  7. Assemble the needed supplies
  8. Review the six rights of medication administration to ensure that it is:
    • For the right student
    • The right medication
    • The right dose
    • Being given at the right time
    • Being given by the right route
    • Being given for the right reason
  9. Be sure to check medication to ensure that it has not expired
  10. Review student’s allergy status
  11. Ensure proper documentation of parent/guardian authorization to administer medication
  12. Follow Student’s Action Plan to ensure the appropriate amount of time has passed prior to administering the student’s seizure medication
  13. Put on gloves
  14. Review the six rights again to be sure that it is:
    • For the right student
    • The right medication
    • The right dose
    • Being given at the right time
    • Being given by the right route
    • Being given for the right reason
  15. Open the bottle of medication
  16. Place the syringe or dropper into the bottle of medication until the end of the syringe/dropper is in the fluid
  17. Draw up the correct dose of medication, ensuring that the dose is correct once the syringe or dropper is removed
    • If the dose is incorrect the fluid can be squirted back into the bottle and withdrawn again
  18. Retract the student’s lower lip
  19. Place the syringe between the lower gum and the cheek on one side of the mouth
  20. Slowly give half the amount of medication into the mouth
  21. Close the lips together and rub on cheek on the outside
  22. Repeat this on the other side of the moth to give the rest of the medication
    • Administer the medication slowly, taking care not to spill the drug outside of the oral cavity
    • Take care not to squirt the medication onto the tongue or into the open throat of the student
    • Do not place the syringe or dropper between their teeth as they may bite it
    • There is no need to open the student’s jaw as the medicine dose does not neen to be swallowed
    • After squirting the medication into the gum remove the syringe/dropper but keep the lip retracted for a few seconds
    • Use gauze swabs to wipe their mouth after
    • If the student is not already lying on their side, place the student on their side
    • Note the time of the and slowly squirt the drug into the mouth between the lip and gum
      • Squirt half of the medication into one side of their mouth and the remaining medication into the other side of the mouth
      • Administer the medication slowly, taking care not to spill the drug outside the oral cavity
      • Take care not to squirt the medication onto the tongue or into the open throat of the child
      • Do not place the syringe or dropper between their teeth as they may bite it
      • There is no need to open the child’s jaw as the medicine does not need to be swallowed
  23. After squirting the medication into the gum remove the syringe/dropper but keep the lip retracted for a few seconds
  24. Use gauze swabs to wipe their mouth after
  25. If the student is not already lying on their side, place the student on their side
  26. Note time of medication administration and document on Seizure Observation Recording Form
  27. If EMS/911 has not been called yet, call 911 or EMS services if indicated on student’s Seizure Action Plan
  28. Stay with the student, monitoring breathing
  29. If breathing stops, begin rescue breaths
  30. Instruct someone to bring an AED, if available
  31. If breathing and heartbeat stop, begin CPR
  32. Once rescue squad arrives, inform them of medication administration, including type of medication, dose, and time
  33. Remember to dispose of all used equipment and bottles of medicine safely out of the reach of students
  34. Remove gloves
  35. Wash hands
  36. Document the date, time and dose of medication given in addition to what was observed during the seizure and recorded on Seizure Observation Recording Form
  37. Follow up with parent/guardian and healthcare provider, as needed
  38. Follow up with the parent or guardian and healthcare provider, as needed.

References:

Butler, S.M., Boucher, E.A., Tobison, J., & Phan, H. (2020). Medication use in schools: Current trends, challenges, and best practices. J Pediatr Pharmacol Ther., 25(1), 7–24. doi: 10.5863/1551-6776-25.1.7

Centers for Disease Control and Prevention. (2022, January 2). Seizure first aid. Retrieved June 6, 2023, from https://www.cdc.gov/epilepsy/about/first-aid.htm

Epilepsy Foundation of America. (2020). Oral rescue medicines. Retrieved June 23, 2023, from https://www.epilepsy.com/treatment/seizure-rescue-therapies/oral-rescue-medicines

Epilepsy Foundation of America. (2020). Seizure training for school nurses: Caring for students. [On-demand course]. Retrieved June 23, 2023, from https://learn.epilepsy.com/courses/take/school-nurse-OD-v2a/lessons/45652454-course-introduction

Hartman, A. L., Devore, C. D., Section on Neurology, American Academy of Pediatrics, Council on School Health, American Academy of Pediatrics, & Doerrer, S. C. (2016). Rescue medicine for epilepsy in education settings. Pediatrics, 137(1), 10.1542/peds.2015-3876. https://doi.org/10.1542/peds.2015-3876

Hoerth, M. & Osborne Shafer, P. (2020, April 16). Oral rescue medications. Retrieved June 9, 2023, from https://www.epilepsy.com/treatment/seizure-rescue-therapies/oral-rescue-medicines

University of Wisconsin Hospitals and Clinics Authority. (2019). Treatment of prolonged seizures with buccal lorazepam or midazolam. Retrieved June 9, 2023, from https://assets.ctfassets.net/4yx69hifndy8/7212.pdf/356405feb2fc7291285c7c7a6bf1d8d2/7212.pdf

Wilfong, A. (2022, September 20). Seizures and epilepsy in children: Refractory seizures. In a D. R. Nordli (Ed.). UpToDate. Retrieved June 9, 2023, from https://www.uptodate.com/contents/seizures-and-epilepsy-in-children-refractory-seizures?search=buccal%20midazolam&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1#


Page last reviewed: February 20, 2025
Page last updated: February 20, 2025


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